Since 2006, Greenville, South Carolina has become a stop along the road for some of the best players in the Boston Red Sox organization. Drive fans have seen the likes of World Series Champions Xander Bogaerts, Clay Buchholz and Anthony Rizzo, 2018 AL MVP Mookie Betts and more. The list that follows represents the players who have gone from "The South to the Show".
| ALUMNI | MLB DEBUT | MLB CLUB | YEARS WITH THE DRIVE | |
| 1 | Clay Buchholz | 8/17/2007 | Boston | 2006 |
| 2 | Michael Bowden | 8/30/2008 | Boston | 2006 |
| 3 | Hunter Jones | 4/20/2009 | Boston | 2006 |
| 4 | Daniel Bard | 5/13/2009 | Boston | 2007-08 |
| 5 | Aaron Bates | 7/6/2009 | Boston | 2006 |
| 6 | Josh Reddick | 7/31/2009 | Boston | 2007-08 |
| 7 | Dustin Richardson | 9/28/2009 | Boston | 2007 |
| 8 | Argenis Diaz | 4/21/2010 | Pittsburgh | 2007 |
| 9 | Felix Doubront | 6/18/2010 | Boston | 2007-08 |
| 10 | Ryan Kalish | 7/31/2010 | Boston | 2008 |
| 11 | Yamaico Navarro | 8/20/2010 | Boston | 2008 |
| 12 | Lars Anderson | 9/6/2010 | Boston | 2007 |
| 13 | Anthony Rizzo | 6/9/2011 | San Diego | 2008-09 |
| 14 | Ryan Lavarnway | 8/18/2011 | Boston | 2009 |
| 15 | Nick Hagadone | 9/1/2011 | Cleveland | 2008-09 |
| 16 | Tim Federowicz | 9/11/2011 | Los Angeles (NL) | 2009 |
| 17 | Che-Hsuan Lin | 4/14/2012 | Boston | 2008 |
| 18 | Will Middlebrooks | 5/2/2012 | Boston | 2009 |
| 19 | Luis Exposito | 5/4/2012 | Baltimore | 2007-08 |
| 20 | Kristopher Negron | 6/7/2012 | Cincinnati | 2007-08 |
| 21 | Stephen Fife | 7/7/2012 | Los Angeles (NL) | 2009 |
| 22 | Miguel Socolovich | 7/14/2012 | Baltimore | 2007 |
| 23 | Casey Kelly | 8/27/2012 | San Diego | 2009 |
| 24 | Jackie Bradley, Jr. | 4/1/2013 | Boston | 2011 |
| 25 | Ryan Pressly | 4/4/2013 | Minnesota | 2010 |
| 26 | Chris McGuiness | 6/7/2013 | Texas | 2009-10 |
| 27 | Jose Alvarez | 6/9/2013 | Detroit | 2008 |
| 28 | Brandon Workman | 7/10/2013 | Boston | 2011 |
| 29 | Drake Britton | 7/20/2013 | Boston | 2010 |
| 30 | Xander Bogaerts | 8/20/2013 | Boston | 2011 |
| 31 | Reymond Fuentes | 8/26/2013 | San Diego | 2010 |
| 32 | Cesar Cabral | 9/2/2013 | New York (AL) | 2010 |
| 33 | Stolmy Pimentel | 9/4/2013 | Pittsburgh | 2009 |
| 34 | Chris Martin | 4/26/2014 | Colorado | 2011 |
| 35 | Alex Hassan | 6/1/2014 | Boston | 2009, 2013 |
| 36 | Garin Cecchini | 6/1/2014 | Boston | 2012 |
| 37 | Mookie Betts | 6/29/2014 | Boston | 2013 |
| 38 | Roman Mendez | 7/8/2014 | Texas | 2010 |
| 39 | Christian Vazquez | 7/9/2014 | Boston | 2010-11 |
| 40 | Anthony Ranaudo | 8/1/2014 | Boston | 2011 |
| 41 | Dan Butler | 8/10/2014 | Boston | 2010 |
| 42 | Hunter Strickland | 9/1/2014 | San Francisco | 2009 |
| 43 | Matt Barnes | 9/9/2014 | Boston | 2012 |
| 44 | Bryce Brentz | 9/17/2014 | Boston | 2014 |
| 45 | Jason Garcia | 4/8/2015 | Baltimore | 2012-14 |
| 46 | Blake Swihart | 5/2/2015 | Boston | 2012 |
| 47 | Travis Shaw | 5/8/2015 | Boston | 2011 |
| 48 | Jonathan Aro | 6/25/2015 | Boston | 2014 |
| 49 | Noe Ramirez | 7/3/2015 | Boston | 2012 |
| 50 | Brian Johnson | 7/21/2015 | Boston | 2013 |
| 51 | Henry Owens | 8/4/2015 | Boston | 2012 |
| 52 | Frankie Montas | 9/2/2015 | Chicago (AL) | 2013 |
| 53 | Carson Blair | 9/6/2015 | Oakland | 2011 |
| 54 | Nefi Ogando | 9/9/2015 | Philadelphia | 2012 |
| 55 | Jeremy Hazelbaker | 4/3/2016 | St. Louis | 2010 |
| 56 | Hunter Cervenka | 4/12/2016 | Atlanta | 2011-12 |
| 57 | Pat Light | 4/26/2016 | Boston | 2013-14 |
| 58 | J.B. Wendelken | 5/8/2016 | Oakland | 2013 |
| 59 | Mike Miller | 6/27/2016 | Boston | 2013 |
| 60 | Andrew Benintendi | 8/2/2016 | Boston | 2015 |
| 61 | Madison Younginer | 8/7/2016 | Atlanta | 2012-13 |
| 62 | Yoan Moncada | 9/2/2016 | Boston | 2015 |
| 63 | Carlos Asuaje | 9/21/2016 | San Diego | 2014 |
| 64 | Manuel Margot | 9/21/2016 | San Diego | 2014 |
| 65 | Justin Haley | 4/5/2017 | Minnesota | 2013 |
| 66 | Ben Taylor | 4/7/2017 | Boston | 2015 |
| 67 | Sam Travis | 5/24/2017 | Boston | 2014 |
| 68 | Austin Maddox | 6/17/2017 | Boston | 2013 |
| 69 | Tzu-Wei Lin | 6/24/2017 | Boston | 2014 |
| 70 | Kyle Martin | 7/20/2017 | Boston | 2013 |
| 71 | Rafael Devers | 7/25/2017 | Boston | 2015 |
| 72 | Jamie Callahan | 9/2/2017 | New York (NL) | 2014-15 |
| 73 | Aaron Wilkerson | 9/25/2017 | Milwaukee | 2015 |
| 74 | Bobby Poyner | 3/31/2018 | Boston | 2016 |
| 75 | Gerson Bautista | 4/17/2018 | New York (NL) | 2016 |
| 76 | Javier Guerra | 5/4/2018 | San Diego | 2015 |
| 77 | Jalen Beeks | 6/7/2018 | Boston | 2015 |
| 78 | Williams Jerez | 8/7/2018 | Los Angeles (AL) | 2015 |
| 79 | Ty Buttrey | 8/16/2018 | Los Angeles (AL) | 2014-15 |
| 80 | Michael Kopech | 8/21/2018 | Chicago (AL) | 2015 |
| 81 | Michael Chavis | 4/20/2019 | Boston | 2015-16 |
| 82 | Darwinzon Hernandez | 4/23/2019 | Boston | 2017 |
| 83 | Shaun Anderson | 5/15/2019 | San Francisco | 2017 |
| 84 | Mike Shawaryn | 6/7/2019 | Boston | 2017 |
| 85 | Stephen Nogosek | 6/19/2019 | New York (NL) | 2016 |
| 86 | Trevor Kelley | 7/2/2019 | Boston | 2016 |
| 87 | Mauricio Dubon | 7/7/2019 | Milwaukee | 2015 |
| 88 | Chandler Shepherd | 8/13/2019 | Baltimore | 2015 |
| 89 | Santiago Espinal | 7/25/2020 | Toronto | 2017 |
| 90 | Jordan Weems | 7/28/2020 | Oakland | 2012-14, 2017 |
| 91 | Kyle Hart | 8/13/2020 | Boston | 2017 |
| 92 | Luis Alexander Basabe | 8/27/2020 | San Francisco | 2016 |
| 93 | Bobby Dalbec | 8/30/2020 | Boston | 2017 |
| 94 | Eduard Bazardo | 4/14/2021 | Boston | 2018 |
| 95 | Jarren Duran | 7/17/2021 | Boston | 2018 |
| 96 | Henry Ramos | 9/5/2021 | Arizona | 2011-12 |
| 97 | Kutter Crawford | 9/5/2021 | Boston | 2018 |
| 98 | Jhonathan Diaz | 9/17/2021 | Los Angeles (AL) | 2017-18 |
| 99 | Denyi Reyes | 5/13/2022 | Baltimore | 2018 |
| 100 | Anderson Espinoza | 5/30/2022 | Chicago (NL) | 2015-16 |
| 101 | Brayan Bello | 7/6/2022 | Boston | 2019, 2021 |
| 102 | Nick Duron | 7/13/2022 | Philadelphia | 2018 |
| 103 | Triston Casas | 9/4/2022 | Boston | 2019 |
| 104 | Thaddeus Ward | 4/1/2023 | Washington | 2019 |
| 105 | Chris Murphy | 6/7/2023 | Boston | 2021 |
| 106 | Brandon Walter | 6/22/2023 | Boston | 2021 |
| 107 | Ceddanne Rafaela | 8/28/2023 | Boston | 2022 |
| 108 | Enmanuel De Jesus | 9/9/2023 | Miami | 2016-18 |
| 109 | Jose Espada | 9/24/2023 | San Diego | 2021 |
| 110 | Ryan Fernandez | 4/3/2024 | St. Louis | 2021-22 |
| 111 | Bradley Blalock | 6/20/2024 | Milwaukee | 2023 |
| 112 | Nick Sogard | 8/2/2024 | Boston | 2021 |
| 113 | Chase Shugart | 8/15/2024 | Boston | 2019, 2021 |
| 114 | Niko Kavadas | 8/16/2024 | Los Angeles (AL) | 2022 |
| 115 | Ryan Zeferjahn | 8/25/2024 | Los Angeles | 2022 |
| 116 | Luis Guerrero | 9/8/2024 | Boston | 2022 |
| 117 | Nick Yorke | 9/16/2024 | Pittsburgh | 2021-22 |
| 118 | Kristian Campbell | 3/27/2025 | Boston | 2023-24 |
| 119 | Christian Koss | 4/1/2025 | San Francisco | 2021 |
| 120 | Hunter Dobbins | 4/6/2025 | Boston | 2023 |
| 121 | Chase Meidroth | 4/11/2025 | Chicago (AL) | 2023 |
| 122 | Matthew Lugo | 5/9/2025 | Los Angeles (AL) | 2022 |
| 123 | Ryan Fitzgerald | 5/16/2025 | Minnesota | 2018 |
| 124 | Marcelo Mayer | 5/24/2025 | Boston | 2022-23 |
| 125 | Kyle Teel | 6/6/2025 | Chicago (AL) | 2023 |
| 126 | Roman Anthony | 6/9/2025 | Boston | 2023 |
| 127 | Wikelman Gonzalez | 6/20/25 | Chicago (AL) | 2023 |
| 128 | Jhostynxon Garcia | 8/22/25 | Boston | 2024 |
| 129 | Brian Van Belle | 8/24/25 | Tampa Bay | 2021-22 |
| 130 | Payton Tolle | 8/29/25 | Boston | 2025 |
| 131 | Connelly Early | 9/9/25 | Boston | 2024 |
| # | Name | Debut Date | Year with Drive | Debut Team |
| 1. | Clay Buchholz | 8/17/2007 | 2006 | Boston |
| 2. | Michael Bowden | 8/30/2008 | 2006 | Boston |
| 3. | Hunter Jones | 4/20/2009 | 2006 | Boston |
| 4. | Daniel Bard | 5/13/2009 | 2007-08 | Boston |
| 5. | Aaron Bates | 7/6/2009 | 2006 | Boston |
| 6. | Josh Reddick | 7/31/2009 | 2007-08 | Boston |
| 7. | Dustin Richardson | 9/28/2009 | 2007 | Boston |
| 8. | Argenis Diaz | 4/21/2010 | 2007 | Pittsburgh |
| 9. | Felix Doubront | 6/18/2010 | 2007-08 | Boston |
| 10. | Ryan Kalish | 7/31/2010 | 2008 | Boston |
| 11. | Yamaico Navarro | 8/20/2010 | 2008 | Boston |
| 12. | Lars Anderson | 9/6/2010 | 2007 | Boston |
| 13. | Anthony Rizzo | 6/9/2011 | 2008-09 | San Diego |
| 14. | Ryan Lavarnway | 8/18/2011 | 2009 | Boston |
| 15. | Nick Hagadone | 9/1/2011 | 2008-09 | Cleveland |
| 16. | Tim Federowicz | 9/11/2011 | 2009 | Los Angeles (NL) |
| 17. | Che-Hsuan Lin | 4/14/2012 | 2008 | Boston |
| 18. | Will Middlebrooks | 5/2/2012 | 2009 | Boston |
| 19. | Luis Exposito | 5/4/2012 | 2007-08 | Baltimore |
| 20. | Kristopher Negron | 6/7/2012 | 2007-08 | Cincinnati |
| 21. | Stephen Fife | 7/7/2012 | 2009 | Los Angeles (NL) |
| 22. | Miguel Socolovich | 7/14/2012 | 2007 | Baltimore |
| 23. | Casey Kelly | 8/27/2012 | 2009 | San Diego |
| 24. | Jackie Bradley, Jr. | 4/1/2013 | 2011 | Boston |
| 25. | Ryan Pressly | 4/4/2013 | 2010 | Minnesota |
| 26. | Chris McGuiness | 6/7/2013 | 2009-10 | Texas |
| 27. | Jose Alvarez | 6/9/2013 | 2008 | Detroit |
| 28. | Brandon Workman | 7/10/2013 | 2011 | Boston |
| 29. | Drake Britton | 7/20/2013 | 2010 | Boston |
| 30. | Xander Bogaerts | 8/20/2013 | 2011 | Boston |
| 31. | Reymond Fuentes | 8/26/2013 | 2010 | San Diego |
| 32. | Cesar Cabral | 9/2/2013 | 2010 | New York (AL) |
| 33. | Stolmy Pimentel | 9/4/2013 | 2009 | Pittsburgh |
| 34. | Chris Martin | 4/26/2014 | 2011 | Colorado |
| 35. | Alex Hassan | 6/1/2014 | 2009, 2013 | Boston |
| 36. | Garin Cecchini | 6/1/2014 | 2012 | Boston |
| 37. | Mookie Betts | 6/29/2014 | 2013 | Boston |
| 38. | Roman Mendez | 7/8/2014 | 2010 | Texas |
| 39. | Christian Vazquez | 7/9/2014 | 2010-11 | Boston |
| 40. | Anthony Ranaudo | 8/1/2014 | 2011 | Boston |
| 41. | Dan Butler | 8/10/2014 | 2010 | Boston |
| 42. | Hunter Strickland | 9/1/2014 | 2009 | San Francisco |
| 43. | Matt Barnes | 9/9/2014 | 2012 | Boston |
| 44. | Bryce Brentz | 9/17/2014 | 2011 | Boston |
| 45. | Jason Garcia | 4/8/2015 | 2012-14 | Boston |
| 46. | Blake Swihart | 5/2/2015 | 2012 | Boston |
| 47. | Travis Shaw | 5/8/2015 | 2011 | Boston |
| 48. | Jonathan Aro | 6/25/2015 | 2014 | Boston |
| 49. | Noe Ramirez | 7/3/2015 | 2012 | Boston |
| 50. | Brian Johnson | 7/21/2015 | 2013 | Boston |
| 51. | Henry Owens | 8/4/2015 | 2012 | Boston |
| 52. | Frankie Montas | 9/2/2015 | 2013 | Chicago (AL) |
| 53. | Carson Blair | 9/6/2015 | 2011 | Oakland |
| 54. | Nefi Ogando | 9/9/2015 | 2012 | Philadelphia |
| 55. | Jeremy Hazelbaker | 4/3/2016 | 2010 | St. Louis |
| 56. | Hunter Cervenka | 4/12/2016 | 2011-12 | Atlanta |
| 57. | Pat Light | 4/26/2016 | 2013-14 | Boston |
| 58. | J.B. Wendelken | 5/8/2016 | 2013 | Oakland |
| 59. | Mike Miller | 6/27/2016 | 2013 | Boston |
| 60. | Andrew Benintendi | 8/2/2016 | 2015 | Boston |
| 61. | Madison Younginer | 8/7/2016 | 2012-13 | Atlanta |
| 62. | Yoan Moncada | 9/2/2016 | 2015 | Boston |
| 63. | Carlos Asuaje | 9/21/2016 | 2014 | San Diego |
| 64. | Manuel Margot | 9/21/2016 | 2014 | San Diego |
| 65. | Justin Haley | 4/5/2017 | 2013 | Minnesota |
| 66. | Ben Taylor | 4/7/2017 | 2015 | Boston |
| 67. | Sam Travis | 5/24/2017 | 2014 | Boston |
| 68. | Austin Maddox | 6/17/2017 | 2013 | Boston |
| 69. | Tzu-Wei Lin | 6/24/2017 | 2014 | Boston |
| 70. | Kyle Martin | 7/20/2017 | 2013 | Boston |
| 71. | Rafael Devers | 7/25/2017 | 2015 | Boston |
| 72. | Jamie Callahan | 9/2/2017 | 2014-15 | New York (NL) |
| 73. | Aaron Wilkerson | 9/15/2017 | 2015 | Milwaukee |
| 74. | Bobby Poyner | 3/31/2018 | 2016 | Boston |
| 75. | Gerson Bautista | 4/17/2018 | 2016 | New York (NL) |
| 76. | Javier Guerra | 5/4/2018 | 2015 | San Diego |
| 77. | Jalen Beeks | 6/7/2018 | 2015 | Boston |
| 78. | Williams Jerez | 8/7/2018 | 2015 | Los Angeles (AL) |
| 79. | Ty Buttrey | 8/16/2018 | 2014-15 | Los Angeles (AL) |
| 80. | Michael Kopech | 8/21/2018 | 2015 | Chicago (AL) |
| 81. | Michael Chavis | 4/20/2019 | 2015-16 | Boston |
| 82. | Darwinzon Hernandez | 4/23/2019 | 2017 | Boston |
| 83. | Shaun Anderson | 5/15/2019 | 2017 | San Francisco |
| 84. | Mike Shawaryn | 6/7/2019 | 2017 | Boston |
| 85. | Stephen Nogosek | 6/19/2019 | 2016 | New York (NL) |
| 86. | Trevor Kelley | 7/2/2019 | 2016 | Boston |
| 87. | Mauricio Dubon | 7/7/2019 | 2015 | Milwaukee |
| 88. | Chandler Shepherd | 8/13/2019 | 2015 | Baltimore |